Structural and Computational Biology
Understanding the molecular underpinnings of biological processes requires an in-depth analysis of the structure and dynamics of proteins, nucleic acids, and the complexes they form. The Department of Biochemistry and Molecular Biology has a strong group of investigators who are using a range of experimental and computational methods to decipher the underlying physical and chemical mechanisms of macromolecular function.
Adams, Erin - Assistant ProfessorStructure and biochemistry of proteins involved in immunological recognition. Characterization of gamma delta T cell receptors and their ligands and activating and inhibitory receptors involved in the innate immune response.
Crosson, Sean - Assistant ProfessorDeciphering the Structure, Function, and Topology of Microbial Signaling Systems
Greene, Geoffrey - ProfessorSteroid hormone regulation of gene networks in reproductive tissues and cancers. Structure and function of nuclear receptors.
Keenan, Robert - Assistant ProfessorStructural biology and directed evolution.
Kent, Stephen - ProfessorApplication of chemistry to the study of proteins. Chemical protein synthesis. Protein mass spectrometry. Functional Proteomics. Mechanism of enzyme catalysis.
Koide, Shohei - Associate ProfessorProtein engineering and design. Peptide self-assembly mechanism and folding. Structural biology of signaling proteins. NMR spectroscopy.
Kossiakoff, Anthony - ProfessorStructure and function of hormone-receptor interactions, enzyme-inhibitor interfaces, and synthetic proteins.
Makinen, Marvin - ProfessorElectron magnetic resonance; enzyme mechanisms; metalloenzymes; molecular dynamics; structural basis of enzyme action.
Moffat, Keith - ProfessorSynchrotron radiation; time-resolved macromolecular crystallography; light-sensitive proteins
Perozo, Eduardo - ProfessorStructure and Dynamics of Ion Channels and transporters
Rice, Phoebe - Associate ProfessorWe study mechanisms of DNA recombination and protein-DNA recognition, combining the tools of biochemistry and x-ray crystallography.
Roux, Benoit - ProfessorTheoretical and computational studies of the structure, dynamics and function of biological macromolecular systems.
Sosnick, Tobin - ProfessorProtein and RNA/ribozyme folding; biological structure and thermodynamics as basis for understanding function.