Protein Engineering Folding and Design
A major technological goal of modern biology is to generate proteins with new and improved properties. In addition to deepening our understanding of the physical and chemical mechanisms that underlie protein function, the ability to confer a desired activity on a protein or enzyme has considerable practical application in the medical, chemical and agricultural world. Investigators in the Department of Biochemistry & Molecular Biology are developing computational and experimental tools that are used to design proteins with novel activities.
Bezanilla, Francisco - ProfessorBiophysics and dynamics of ion channels
Getz, Godfrey - ProfessorStructure and function of apolipoproteins in lipoprotein assembly, and in atherosclerosis and Alzheimers disease pathogenesis.
Greene, Geoffrey - ProfessorSteroid hormone regulation of gene networks in reproductive tissues and cancers. Structure and function of nuclear receptors.
Keenan, Robert - Assistant ProfessorStructural biology and directed evolution.
Kent, Stephen - ProfessorApplication of chemistry to the study of proteins. Chemical protein synthesis. Protein mass spectrometry. Functional Proteomics. Mechanism of enzyme catalysis.
Koide, Shohei - Associate ProfessorProtein engineering and design. Peptide self-assembly mechanism and folding. Structural biology of signaling proteins. NMR spectroscopy.
Kossiakoff, Anthony - ProfessorStructure and function of hormone-receptor interactions, enzyme-inhibitor interfaces, and synthetic proteins.
Makinen, Marvin - ProfessorElectron magnetic resonance; enzyme mechanisms; metalloenzymes; molecular dynamics; structural basis of enzyme action.
Meredith, Stephen - Associate ProfessorLipid-protein interactions; lipoprotein structure; surface phenomena in biology.
Moffat, Keith - ProfessorSynchrotron radiation; time-resolved macromolecular crystallography; light-sensitive proteins
Perozo, Eduardo - ProfessorStructure and Dynamics of Ion Channels and transporters
Rock, Ronald - Assistant ProfessorMolecular motors; cytoskeletal organization; single-molecule biophysics
Roux, Benoit - ProfessorTheoretical and computational studies of the structure, dynamics and function of biological macromolecular systems.
Sosnick, Tobin - ProfessorProtein and RNA/ribozyme folding; biological structure and thermodynamics as basis for understanding function.