Glyn Dawson
Research Summary / Selected Publications
My long term interest has been in the biochemistry of lysosomal storage diseases and the reason for the early neuronal cell death and demyelination associated with theseinherited diseases. This has led us to study lipid-linked signal transduction in isolated neurons, astrocytes and oligodendrocytes. More recently we have focussed on the role of the sphingolipid ceramide as a promoter of cell death (apoptosis) in many different cell types. We are interested in drugs which reduce apoptosis (neuroprotective drugs ) which could reverse neurodegeneration and in proapoptotic drugs such as oleoylethanolamine which could be anti-cancer drugs. We make extensive use of cell culture, gene transfection, protein purification, lipid isolation, in vitro enzyme assays and a range of analytical and biochemical methods including mass spectrometry.
My long term interest has been in the biochemistry of lysosomal storage diseases and the reason for the early neuronal cell death and demyelination associated with theseinherited diseases. This has led us to study lipid-linked signal transduction in isolated neurons, astrocytes and oligodendrocytes. More recently we have focussed on the role of the sphingolipid ceramide as a promoter of cell death (apoptosis) in many different cell types. We are interested in drugs which reduce apoptosis (neuroprotective drugs ) which could reverse neurodegeneration and in proapoptotic drugs such as oleoylethanolamine which could be anti-cancer drugs. We make extensive use of cell culture, gene transfection, protein purification, lipid isolation, in vitro enzyme assays and a range of analytical and biochemical methods including mass spectrometry.
Kilkus J, Goswami R, Dawson SA, Testai FD, Berdyshev E, Han X, and Dawson G (2008) Differential regulation of sphingomyelin synthesis and catabolism in oligodendrocytes and neurons. J. Neurochem. 106: 1745-1757.
Qin J, Goswami R, Dawson S, Dawson G. (2008) Expression of the receptor for advanced glycation end products in oligodendrocytes in response to oxidative stress. J Neurosci Res. 86: 2414-2422.
Kroes, R.A., Dawson, G. and Moskal, J.R. (2007) Focussed microarray analysis of glyco-gene expression in human glioblastomas. J. Neurochem. 103 Suppl 1:14-24.
Goswami, R., Ahmed, M., Kilkus, T., Dawson, S.A. and Dawson, G (2005) Differential regulation of ceramide in lipid-rich microdomains (Rafts): Antagonistic role of palmitoyl:protein thioesterase and neutral sphingomyelinase 2, J. Neurosci. Res. 81. 208-217.
Goswami, R., Singh, D., Phillips, G., Kilkus, J., and Dawson, G (2005). Ceramide regulation of the tumor supressor phosphatase PTEN in Rafts isolated neurotumor cell lines. J. Neurosci. Res. 81: 541-550.
Hobert, J.A and Dawson, G. (2006) Neuronal Ceroid Lipofuscinoses Therapeutic Strategies: Past, Present and Future. Biochim. Biophys Acta. 1762: 945-953
Hobert, J.A., and Dawson, G. (2007). A novel role of the batten disease gene CLN3: association with BMP synthesis. Biochem. Biophys. Res. Commun. 358: 111-116.
Qin,,J., Goswami,R, Balabanov, R, and Dawson, G., (2007). Oxidized phosphatidylcholine (OxPC) is a marker for neurodegeneration multiple sclerosis brain .J. Neurosci Res. 85: 977-984
Testai, F.D., Landek, M.A, Goswami, R., Ahmed, M., and Dawson, G. (2004). Acid sphingomyelinase and
inhibition by phosphate ion: role of PtdIns(3,4,5)P3 in oligodendrocyte signaling. J. Neurochem. 89: 636-644
Testai, F.D., Landek, M.A. and Dawson, G. (2004). Regulation of sphingomyelinases in cells of the
oligodendrocyte lineage. J. Neurosci. Res. 75: 66-74
Kilkus J, Goswami R, Dawson SA, Testai FD, Berdyshev E, Han X, and Dawson G (2008) Differential regulation of sphingomyelin synthesis and catabolism in oligodendrocytes and neurons. J. Neurochem. 106: 1745-1757.
Qin J, Goswami R, Dawson S, Dawson G. (2008) Expression of the receptor for advanced glycation end products in oligodendrocytes in response to oxidative stress. J Neurosci Res. 86: 2414-2422.
Kroes, R.A., Dawson, G. and Moskal, J.R. (2007) Focussed microarray analysis of glyco-gene expression in human glioblastomas. J. Neurochem. 103 Suppl 1:14-24.
Goswami, R., Ahmed, M., Kilkus, T., Dawson, S.A. and Dawson, G (2005) Differential regulation of ceramide in lipid-rich microdomains (Rafts): Antagonistic role of palmitoyl:protein thioesterase and neutral sphingomyelinase 2, J. Neurosci. Res. 81. 208-217.
Goswami, R., Singh, D., Phillips, G., Kilkus, J., and Dawson, G (2005). Ceramide regulation of the tumor supressor phosphatase PTEN in Rafts isolated neurotumor cell lines. J. Neurosci. Res. 81: 541-550.
